Steele Lab

The Steele Lab combines transcranial magnetic stimulation (TMS) and neuroimaging research techniques with the goal of developing novel treatments for substance use disorders (SUDs). Current studies involve targeting dysregulated circuits in SUD with TMS to elicit neuroplastic change and identify malleable circuits that, with chronic treatment, could lead to positive long-term outcomes treating SUDs. Acute and chronic neuroplasticity is assessed with both electroencephalography (EEG) and functional magnetic resonance imaging (fMRI). 

Steele Lab Director

Vaughn R Steele, PhD

Director
Steele Lab
Assistant Professor of Psychiatry,
Yale University School of Medicine

Team Members

Hannah Olson M.S.

Research Assistant I

Hannah earned her BA in Psychology with a minor in Spanish from the University of Wisconsin-La Crosse in 2016 and her MS in Neuroscience from the University of Hartford in 2020. She joined the Steele Lab in September of 2020. In the future, Hannah intends to pursue a Clinical Psychology PhD with a focus in Neuropsychology. Outside of work, she enjoys coaching and playing volleyball and spending time in nature.

Email: Hannah.Olson@hhchealth.org

Current Research Projects

Neuroplastic Change Induced by Transcranial Magnetic Stimulation (TMS)

This study examines whether TMS can modulate activity in executive functioning circuits in the brains of healthy people as well as those with opioid use disorder (OUD) in order to assess the potential of these circuits as targets for treatment of OUD with TMS. [Funded by NIH/NIDA and HHC]  

Modulation of Circuits in an Opioid Use Disorder (OUD) sample

This study uses fMRI and TMS to explore how intermittent theta burst stimulation (iTBS) induces neuroplastic change in individuals with OUD. Results could inform future studies of iTBS as a treatment for OUD. [Funded by NIH/NIDA and HHC]

Recent Publications

2020

Steele, V. R. (2020). Transcranial magnetic stimulation as an interventional tool for addiction. Frontiers in Neuroscience: Neural Technologies, 14, 592343https://www.frontiersin.org/articles/10.3389/fnins.2020.592343/full

Steele, V. R. (2020). Transcranial magnetic stimulation and addiction: Toward uncovering known unknowns. EBioMedicine, 57, 102839https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(20)30214-0/fulltext

Lee, M. R., Caparelli, E. C., Leff, M., Steele, V. R., Maxwell, A. M., McCullough, K., & Salmeron, B. J. (2020). Repetitive transcranial magnetic stimulation delivered with an H-coil to the right insula reduces functional connectivity between insula and medial prefrontal cortex. Neuromodulation: Technology at the Neural Interface, 23(3), 384-392. https://onlinelibrary.wiley.com/doi/10.1111/ner.13033


2019

Maurer, J. M., Steele, V. R., Vincent, G. M., Rao, V., Calhoun, V. D., & Kiehl, K. A. (2019). Adolescent psychopathic traits negatively related to hemodynamic activity within the basal ganglia during error-related processing. Journal of Abnormal Child Psychology, 47(12), 1917-1929. https://link.springer.com/article/10.1007/s10802-019-00560-3

Steele, V. R., Maxwell, A. M., Ross, T. J., Stein, E. A., & Salmeron, B. J. (2019). Accelerated intermittent theta-burst stimulation as a treatment for cocaine use disorder: A proof-of-concept study. Frontiers in Neuroscience: Neural Technologies, 13, 1147. https://www.frontiersin.org/articles/10.3389/fnins.2019.01147/full

Liu, Y., van den Wildenberg, W. P. M., de Graaf, Y., Ames, S. L., Baldacchino, A., Bø, R., Cadaveira, F., Campanella, S., Christiansen, P., Claus, E. D., Colzato, L. S., Filbey, F. M., Foxe, J. F., Garavan, H., Hendershot, C. S., Hester, R., Jester, J. R., Karoly, H. C., Kräplin, A., Kreusch, F., Landrø, N. I., Littel, M., Steins-Loeber, S., London, E. D., López-Caneda, E., Lubman, D. I., Luijten, M., Marczinski, C. A., Metrik, J., Montgomery, C., Papachristou, H., Park, S. M., Paz, A. L., Petit, G., Prisciandaro, J. J., Quednow, B. B., Ray, L. A., Roberts, C. A., Roberts, G. M. P., de Ruiter, M. B., Rupp, C. I., Steele, V. R., Sun, D., Takagi, M., Tapert, S. F., van Holst, R. J., Verdejo-Garcia, A., Vonmoos, M., Wojnar, M., Yao, Y., Yücel, M., Zack, M., Zucker, R. A., Huizenga, H. M., & Wiers, R. W. (2019). Is (poly-) substance use associated with impaired inhibitory control? A mega-analysis controlling for confounders. Neuroscience & Biobehavioral Reviews, 105, 288-304. https://www.sciencedirect.com/science/article/pii/S014976341830633X

Ekhtiari, H., Tavakoli, H., Addolorato, G., Baeken, C., Bonci, A., Campanella, S., Castelo-Branco, L., Challet-Bouju, G., Clark, V. P., Claus, E. D., Dannon, P. N., Del Felice, A., den Uyl, T., Diana, M., di Giannantonio, M., Fedota, J. R., Fitzgerald, P., Gallimberti, L., Grall-Bronnec, M., Herremans, S. C., Herrmann, M. J., Jamil, A., Khedr, E., Kouimtsidis, C., Kozak, K., Krupitsky, E., Lamm, C., Lechner, W. V., Madeo, G., Malmir, N., Martinotti, G., McDonald, W., Montemitro, C., Nakamura-Palacios, E., Nasehi, M., Noël, X., Nosratabadi, M., Paulus, M., Pettorruso, M., Pradhan, B., Praharaj, S. K., Rafferty, H., Sahlem, G., Salmeron, B. J., Sauvaget, A., Schluter, R. S., Sergiou, C., Shahbabaie, A., Sheffer, C., Spagnolo, P. A., Steele, V. R., Yuan, T-F., van Dongen, J., Van Waes, V., Venkatasubramanian, G., Verdejo-García, A., Verveer, I., Welsh, J., Wesley, M. J., Witkiewitz, K., Yavari, F., Zarrindast, M-R., Zawertailo, L., Zhang, X., Cha, Y-H., George, T. P., Frohlich, F., Goudriaan, A. E., Fecteau, S., Daughters, S., Stein, E. A., Fregni, F., Nitsche, M. A., Zangen, A., Bikson, M., Hanlon, C. A. (2019). Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead. Neuroscience & Biobehavioral Reviews, 104, 118-140. https://www.sciencedirect.com/science/article/abs/pii/S0149763419303070


*For a full list of publications, see Google Scholar. Email Dr. Steele or the Steele Lab to request PDFs. 

In The News

...

Olin Neuropsychiatry Research Center

         Lab Contct Info:

            Email:

            steele.lab@hhchealth.org

            Phone:

            860.545.7965