Bipolar-Schizophrenia Network for Intermediate Phenotypes-2 Study

This is a multi-site study seeking to understand the relationship between the biology and presentation of mental health symptoms in people with schizophrenia, schizoaffective disorder, and bipolar disorder.

This is done by completing clinical interviews concerning your medical and psychiatric history in addition to physiology measures such as cognitive testing, EEG, eye-tracking MRI, and collection of a DNA sample.

Researchers on this team:

  • Godfrey Pearlson, MD
  • Michael Stevens, PhD
  • David Glahn, PhD
  • Michal Assaf, MD

Who can participate?

Individuals between the ages of 18 – 60 may be eligible to participate. You may qualify if any of the following apply to you:

  1. You have been diagnosed with either schizophrenia, schizoaffective disorder, or bipolar disorder
  2. You experience hearing or seeing things that others couldn’t, or have strong beliefs that other people do not have
  3. You have little-to-no history of mental health issues or treatment

What will I do if I participate?

Qualified participants will complete the following.

  • Clinical interviews concerning your medical and psychiatric history, family psychiatric history, mood symptoms, and other lifetime experiences
  • Donation of a DNA sample (either blood or saliva)
  • Surveys that ask about life experiences and personality characteristics
  • A safe and non-invasive fMRI scan
  • A non-invasive electroencephalogram (EEG) test while you complete listening and visual tasks. This test is used to measure the electrical brain activity that your brain naturally produces.
  • A non-invasive eye-tracking test that will measure how well you can follow a moving target on a computer screen with your eyes
  • Cognitive testing that assesses memory, visual skills, concentration, and motor skills

All study procedures will take approximately 12 – 14 hours to complete. These tasks are split up over at least two appointment days. There are no medications or treatment involved in this study. You may have the option to not do any particular task you are not comfortable with. Any and all information collected about you will be kept confidential. Only the research staff will have access to this information.

What do I get out of this?

Participants are compensated $20 per hour when completing study procedures (via a prepaid credit card). You may also request a CD copy of your MRI, if desired. You will be provided with a lunch voucher for the IOL cafeteria should your visit span through lunchtime. We can provide transportation to and from the appointment using Uber or Valley Cab services if needed.

Additionally, through your participation, you may provide information that will benefit future patients with schizophrenia, schizoaffective disorder, or bipolar disorder.

How do I get involved?

If interested, please complete an online screening form (following the link below) to determine your eligibility for the study. All responses to this screening form are kept confidential and will only be reviewed by the research staff. If you prefer to go over these questions over the phone, please call or text Anna Bertoldo at 203.641.0467.

Who can I contact with questions about the study?

If you have any questions about the study please contact Anna Bertoldo. You may call or text her at 203.641.0467 or email her at

Adult Mental Health Resources

Walk-In Care

  • Hartford Behavioral Health
    • 2550 Main Street, Hartford
      • Tuesdays and Wednesdays 9 – 10:30 AM
    • 860.548.0101 ext 354
  • Wheeler Clinic
    • 999 Asylum Avenue, Hartford
      • Monday thru Thursdays 10 AM – 5:30 PM; Fridays 9 AM – 3:30 PM
  • Community Health Services

Additional Services

The Institute of Living

Olin Neuropsychiatry Research Center